Coming into Monday night's game against Toronto, Tampa Bay right-hander Jake Odorizzi had gone three straight starts without allowing a run.
It took just three pitches for the Blue Jays to snap Odorizzi's scoreless streak.
Devon Travis had a career-high four hits, including the go-ahead single in the seventh inning, and the Blue Jays beat the Rays 7-5 on Monday.
Odorizzi came in riding a streak of 20 2-3 scoreless innings, the longest active run in the AL, but he couldn't add to it. Travis tripled on Odorizzi's second pitch of the game and scored when Bautista followed with a first-pitch sacrifice fly.
"I wouldn't say I really had my best stuff tonight," Odorizzi said. "Definitely not as good as any start previously since the All-Star break. I had to battle a lot."
Odorizzi allowed four runs and eight hits in 5 1-3 innings. He walked three and struck out four.
"I don't think (Odorizzi) was as sharp as he's shown," Rays manager Kevin Cash said.
Tampa Bay's loss, coupled with Minnesota's win over Houston, gave the Rays the worst record in the AL at 45-66.
Edwin Encarnacion hit his 299th career home run as the Blue Jays snapped a three-game losing streak against Tampa Bay.
Toronto is an MLB-best 45-26 since being swept at home by the Rays from May 16-18. Tampa Bay has gone 26-47 since, the worst record in the majors.
Travis has been batting leadoff regularly since an Aug. 1 win at Houston. He's 11 for 31 with three home runs and five RBIs since moving to the top of the order.
"He's on some kind of roll," manager John Gibbons said. "He's been doing a little bit of everything for us."
Joaquin Benoit (2-1) worked one inning for the win. Roberto Osuna gave up Logan Forsythe's solo homer in the ninth but finished for his 25th save.
Rays left-hander Xavier Cedeno (3-4) was replaced after walking the first two batters of the seventh. Dylan Floro came on and walked pinch-hitter Russell Martin to load the bases but got pinch-hitter Justin Smoak to bounce back to the mound, with Michael Saunders forced at home. Saunders took out catcher Bobby Wilson as he slid in, preventing what might have been an inning-ending double play. Travis followed with an RBI single and Bautista hit a two-run double.
Cash said the double play became a challenge after Floro bobbled Smoak's bouncer.
"We're an executed play away from getting out of the inning with no runs," Cash said. "We didn't execute the play and then they bust it open."
Mikie Mahtook and Steve Souza Jr. tied it with RBI doubles in the fourth but the Blue Jays regained the lead on Encarnacion's two-out, two-run single in the bottom half.
"They keep coming at you," Tampa Bay's Brad Miller said of Toronto. "We kept firing and firing and firing. They just did a better job of it."
Tampa Bay tied it 4-all and chased knuckleballer R.A. Dickey on Miller's two-run double in the fifth. Miller has at least one RBI in six straight games.
The Rays put runners at second and third with no outs in the seventh but couldn't score. Evan Longoria struck out and Forsythe didn't tag from third on Miller's fly ball to Bautista in right.
"We know where Bautista is at right now," Cash said. "He's big time player, he shows up pretty big in big situations. That's a throw that we've seen him make over and over."
FIRST TIME AT FIRST
Miller played first base for the first time in his career. "He looked very comfortable over there," Cash said.
The Rays allowed four or more runs for the third time in 14 games.
Blue Jays: OF Kevin Pillar (left thumb) was placed on the 15-day DL. Toronto recalled OF Darrell Ceciliani from Triple-A Buffalo.
Rays: LHP Drew Smyly (3-11, 5.14) is 1-0 with a 2.37 ERA in his past three starts. He's 2-0 with a 0.56 ERA in four career games at Toronto, including two starts.
Blue Jays: RHP Marco Estrada (7-4, 2.92) has won consecutive starts after going winless in his previous four outings. Estrada allowed one run in seven innings to beat Houston on Aug. 3.