The company says it teamed with self-driving truck maker, Otto, and the state of Colorado for the feat. The trailer, loaded with Budweiser beer, began the self-driving trip at a weigh station in Fort Collins, Colorado, and ran along Interstate 25 through Denver before wrapping up in Colorado Springs.
The company says a professional truck driver was on board for the entire route and monitored the trip from the cab's sleeper berth. It didn't say when the shipment took place.
Anheuser-Busch says it hopes to see self-driving technology widely deployed.
Otto was recently acquired by Uber.